Thermo Scientific Ion Max API Source
- H-ESI II probe with dual desolvation zone technology
- Sweep gas to reduce chemical noise
- 60° interchangeable ion probe orientation
- Removable metal ion transfer capillary provides vent-free maintenance Vacuum System
- Differentially pumped vacuum system with final vacuum <1 x 10⁻⁹
- Two split-flow turbomolecular pumps and one rotary vane pump
- Seven vacuum regions
Quadrupole Mass Filter
- Thermo Scientific™ HyperQuad™ mass filter provides increased ion transmission
- Variable precursor ion isolation width selection from 0.4 Da to full mass range
Ion Optics
- RF lens stacked-ring radio frequency ion guide captures and efficiently focuses the ions into a tight beam. Large variable spacing between electrodes allows for better pumping efficiency and improved ruggedness.
- Bent flatapole ion guide reduces noise by preventing neutrals and high-velocity clusters from entering the quadrupole
Orbitrap Mass Analyzer
- Nitrogen-filled C-Trap
- Highly efficient ion transfer to Thermo Scientific™ Orbitrap™ mass analyzer
- Straight multipole collision cell for HCD
- Orbitrap mass analyzer with 5 kV central electrode voltage
- Low-noise image current preamplifier
- 16-bit signal digitalization
Data Acquisition
- Ultrafast real-time data acquisition and instrument control system
- Fully automated calibration via instrument control software
- Automatic Gain Control
Superior performance
The Q Exactive Focus mass spectrometer combines quadrupole precursor selection with high-resolution, accurate-mass detection to produce sensitivity that rivals triple quadrupole mass spectrometers and resolution that surpasses Q-TOF instruments.
- Exceptional sensitivity thanks to superior selectivity that eliminates interferences allowing lower limits of detection and quantitation
- Fast polarity switching so more classes of compounds can be processed in a single analysis
- High scan speeds for compatibility with fast chromatography and high-throughput screening
- Resolution superior to Q-TOF instruments for more confident identification and confirmation
- Exceptionally wide linear dynamic range
Exceptional flexibility
The unique hybrid quadrupole-Orbitrap configuration provides exceptional flexibility, allowing Q Exactive Focus instruments to perform both targeted and untargeted screening with confident identification and confirmation. Q Exactive Focus instruments can take advantage of high-resolution, accurate-mass in a number of quantification approaches, including:
- Full-scan – data-dependent MS/MS (FS-ddMS2) acquisition for ultimate scan speed and quantitative performance
- *Variable data-independent acquisition (vDIA) for qualitative coverage for screening unknowns without compromising quantitative performance
- Selected-ion monitoring (SIM) for simple setup and highest sensitivity
- Parallel-reaction monitoring (PRM) for high selectivity and high throughput with confident confirmation
Powerful Software
Application-specific software is available to make full use of the power of the Q Exactive Focus instrument. The system’s unique data acquisition function enables ultrafast real-time data acquisition and instrument control, fully automated calibration via instrument control software, and automatic gain Control.
For component identification during targeted and untargeted analysis, the Thermo Scientific™ TraceFinder™ software includes libraries of high-resolution accurate-mass (HRAM) spectra. Compounds commonly targeted in food and environmental analyses, and in clinical research and forensic/toxicological studies, are represented by several thousand HRAM spectra. Combined with TraceFinder data analysis software, the Q Exactive Focus offers a powerful, yet simple-to-use solution for food safety, environmental, clinical research, forensic, and toxicological screening.