News from Promega

Detect Metabolites Using Bioluminescent Assays 

Measuring metabolites is now simpler.Whether you want to assess glucose, glutamate, lactate or glutamine/glutamate for your research, there is a luminescent-based assay that can detect these metabolites directly from various biological samples.

Download poster - Measuring changes in tumor
Download poster - Metabolite detection 

T cell Activation Bioassays

Discover new strategies for immunotherapy using the T Cell Activation Bioassays. These bioluminescent cell-based assays overcome the limitations of existing assays and can be used for the discovery and development of novel biologics such as bispecific antibodies and CAR-T cell therapies.

Immunotherapy strategies aimed at inducing, strengthening or engineering T cell responses have emerged as promising approaches for the treatment of diseases such as cancer and autoimmunity. T cell activation is initiated by engagement of the TCR/CD3 complex and the co-stimulatory receptor CD28, with TCR/CD3 engagement activating the NFAT pathway and TCR/CD3 + CD28 co-engagement activating NFAT, AP-1 and NF-κB pathways and inducing IL-2 production.

Download poster - reporter based T cell activation
Download poster - cell activation